American Journal of Life Sciences

Volume 3, Issue 1, January 2015

  • Relationship between eNOS 894G>T Polymorphism and the Antihypertensive Efficiency of Two Dihydropyridine Calcium Channel Blocker Drugs, Azelnidipine and Nitrendipine, in Chinese EH Patients

    Zhiying Luo, Fazhong He, Jianquan Luo, Wei Zhang

    Issue: Volume 3, Issue 1-4, January 2015
    Pages: 1-6
    Received: Oct. 23, 2014
    Accepted: Oct. 25, 2014
    Published: Nov. 24, 2014
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    This article belongs to the Special Issue Pharmacogenomics & Personalized Medicine
    Abstract: Background: Dihydropyridine calcium-channel blockers (dCCBs) were widely used in anithypertensive treatment. The aim of this study was to examine the effect of polymorphisms of CACNA1C, eNOS and RGS2 on the antihypertensive efficiency of dihydropyridine calcium channel blocks (dCCBs) in Chinese patients with essential hypertension (EH). Methods: A ... Show More
  • Moderate Effect of GGCX Polymorphisms on Patients Warfarin Dosage Requirement- A Meta-Analysis

    Zhiying Luo, Xi Li, Mouze Liu, Yan Shu, Jiye Yin, Xiaoping Chen, Jianquan Luo, Xiaobing Li, Wei Zhang

    Issue: Volume 3, Issue 1-4, January 2015
    Pages: 7-13
    Received: Nov. 19, 2014
    Accepted: Nov. 22, 2014
    Published: Dec. 27, 2014
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    This article belongs to the Special Issue Pharmacogenomics & Personalized Medicine
    Abstract: Objective: Association studies on the effects of GGCX gene polymorphisms on warfarin stable dose have shown conflicting results. The aim of this study is to quantitatively summarize whether GGCX gene polymorphisms have potential roles in warfarin dose requirement. Methods: Publications were searched in PubMed, Medline and ISI Web of Knowledge and c... Show More
  • Gender, but Not CYP2C19 Genotypes and CYP3A Phenotypes, is a Major Determinant of Ilaprazole Pharmacokinetic

    Shan Cao, Gan Zhou, Yao Chen, Dong Guo, Zhi-rong Tan, Lan Fan, Hai-tang Hu, Xiang-hong Qin, Hong-hao Zhou, Dong-sheng Ouyang, Wei Zhang

    Issue: Volume 3, Issue 1-4, January 2015
    Pages: 14-20
    Received: Sep. 16, 2014
    Accepted: Nov. 24, 2014
    Published: Jan. 27, 2015
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    This article belongs to the Special Issue Pharmacogenomics & Personalized Medicine
    Abstract: The purpose of the study was to assess the impact of CYP2C19 genotypes, CYP3A phenotypes and gender-related difference on the pharmacokinetics of new proton pump inhibitor ilaprazole. Twenty-four healthy Chinese volunteers (age 24.0  1.9 years) were enrolled in an open-label study stratified for gender (12 males and 12 females) and their CYP2C19 g... Show More