Volume 3, Issue 1-2, January 2015, Page: 48-57
The Choice of Informative Parameters of the Cardiovascular System for Assessment of Physiological Effects of Hypogravity
Anton Cherepov, Lab of Neurobiology of Memory, P. K. Anokhin Institute of Normal Physiology, Moscow, Russia
Daria Pozdeeva, Lab of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia
Elena Arkhipova, Lab of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia
Received: Dec. 19, 2014;       Accepted: Dec. 23, 2014;       Published: Dec. 31, 2014
DOI: 10.11648/j.ajls.s.2015030102.18      View  3167      Downloads  135
Abstract
Changes in cardiovascular system (CVS) under conditions of hypogravity simulated using 7- and 21-day ortho- and antiorthostatic hypokinesia at different angles were studied. The aim of the experiment was selection of informative CVS parameters most sensitive to these conditions. Simultaneous recording of 26 CVS parameters on a spiroartheriocardiorythmograph showed that the most sensitive parameters were blood pressure (BP) variability indexes in functional tests: differences in groups with varying degrees of orthostatic hypokinesia (+ 9.6˚ and + 15˚) were observed starting from the first week of the experiment. By day 21, pronounced changes in the total spectral power of diastolic BP variability were noted in the group exposed to constant antiorthostasis. This parameter significantly surpassed the corresponding value in the groups with milder conditions. Significant increase in the LF component of diastolic BP in groups exposed to severe antiorthostasis and orthostasis was detected. Presumably, autonomic mechanisms affecting the systolic and diastolic BP under conditions of hypogravity simulation are different, at least partially.
Keywords
Systolic and Diastolic Blood Pressure, Simulated Hypogravity, Bed Rest, Heart rate Variability, Blood Pressure Variability
To cite this article
Anton Cherepov, Daria Pozdeeva, Elena Arkhipova, The Choice of Informative Parameters of the Cardiovascular System for Assessment of Physiological Effects of Hypogravity, American Journal of Life Sciences. Special Issue:Space Flight Factors: From Cell to Body. Vol. 3, No. 1-2, 2015, pp. 48-57. doi: 10.11648/j.ajls.s.2015030102.18
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